Ammonium Hydroxide → 2546-41-0

HRID 1897426Notes

Reaction equation

HRID 1897426 reaction equation
C([O:4][C:5]1[CH:10]=[CH:9][C:8]([F:11])=[CH:7][C:6]=1[CH2:12][C:13]([OH:15])=[O:14])(=O)C.[OH-].[NH4+].C(Cl)Cl.CO.CC(O)=O>CO>[F:11][C:8]1[CH:9]=[CH:10][C:5]([OH:4])=[C:6]([CH2:12][C:13]([OH:15])=[O:14])[CH:7]=1

Participants

5

Reactant 3

HCID 14923Ammonium HydroxideHCID 21877243DCM MeOH AcOHHCID 67411043HCID 67411043, compound

Product 1

HCID 497588302546-41-0

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Compound (7p) (3.5 g, 16.5 mmol) was dissolved in 65 mL of MeOH, and 7 mL of ammonium hydroxide (49.5 mmol) was added. The mixture was stirred at room temperature overnight and then checked by TLC (DCM/MeOH/AcOH (9:1:0.15)), HPLC and MS. No starting material was observed. The material was concentrated to dryness to give the desired product (8p) which was carried onto the next step directly. MS (APCI−) m/z 168.9 (M−H), 338.7 (2M−H) was detected.

Workup

  1. concentrationThe material was concentrated to dryness

Sources & evidence

ORD record
ord-84a24689a1d2475c8c5b9cd671e2351d
Source dataset
uspto-grants-2013_08
Patent number
US08518983B2

Reaction notes

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