Potassium Carbonate → 1-Bromo-2-(2,4-difluorophenoxy)-4-methyl-5-nitrobenzene
Reaction equation
[Br:1][C:2]1[CH:7]=[C:6]([N+:8]([O-:10])=[O:9])[C:5]([CH3:11])=[CH:4][C:3]=1Br.[F:13][C:14]1[CH:19]=[C:18]([F:20])[CH:17]=[CH:16][C:15]=1[OH:21].C([O-])([O-])=O.[K+].[K+]>>[Br:1][C:2]1[CH:7]=[C:6]([N+:8]([O-:10])=[O:9])[C:5]([CH3:11])=[CH:4][C:3]=1[O:21][C:15]1[CH:16]=[CH:17][C:18]([F:20])=[CH:19][C:14]=1[F:13]Participants
Conditions
- Temperature
- 100 °C
Procedure
A mixture of 1,2-dibromo-4-methyl-5-nitrobenzene (84.3 g, 286 mmol), 2,4-difluorophenol (37.2 g, 286 mmol), and K2CO3 (43.5 g, 315 mmol) were heated to 100° C. for 45 hours. The reaction mixture was cooled to room temperature and then stored in a 5° C. refrigerator overnight. The reaction mixture was poured into 1200 mL of ice water all at once. The resulting damp solid was collected, partially ground up, and stirred in 900 mL H2O for 45 minutes. The solid was collected by filtration and rinsed with 700 mL of water portion-wise. The resulting solid was dried under high vacuum overnight to yield 93.5 g of a brown solid (95% yield). 1H NMR (400 mHz, CDCl3) δ 8.38 (s, 1H), 7.18 (m, 1H), 7.03 (m, 1H), 6.97 (m, 1H), 6.52 (s, 1H), 2.50 (s, 3H).
Workup
- temperatureThe reaction mixture was cooled to room temperature
- customstored in a 5° C.
- customrefrigerator overnight
- customThe resulting damp solid was collected
- filtrationThe solid was collected by filtration
- washrinsed with 700 mL of water portion-wise
- customThe resulting solid was dried under high vacuum overnight
Sources & evidence
- ORD record
- ord-1aa887e4b89a4b5b96e64871ce10996b
- Source dataset
- uspto-grants-2013_08
- Patent number
- US08518983B2
Reaction notes
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