反应详情

To a solution of 2-[1-(2,2-dimethoxyethyl)-1H-indazol-5-yloxy]-5-fluorobenzonitrile (1.42 g, 4.16 mmol) in dichloromethane (62 mL) was added iodotrimethylsilane (3.33 g, 16.64 mmol) portion-wise over 3 hours. The mixture was stirred at room temperature for 2 hours. Aqueous NaHCO3 (60 mL) was added to the mixture and it was extracted with ethyl acetate (2×50 mL). The combined extracts were washed with Na2S2O4, brine, dried over MgSO4, and concentrated under reduced pressure. The crude product was used in the next reaction without further purification.

1. extractionwas extracted with ethyl acetate (2×50 mL)
2. washThe combined extracts were washed with Na2S2O4, brine
3. dry with materialdried over MgSO4
4. concentrationconcentrated under reduced pressure
5. customThe crude product was used in the next reaction without further purification