反应详情

温度

0 °C

HBr (3.84 mL, 34.0 mmol) was added to 6-chloro-2-(4-diethoxymethyl-pyridin-3-yl)-1-methyl-1H-benzoimidazole (0.470 g, 1.359 mmol), and the reaction mixture was stirred for 10 min. The reaction was cooled to 0° C. and quenched with saturated aqueous sodium bicarbonate solution. It was extracted with DCM twice. The organic layer was dried over sodium sulfate and concentrated in vacuo to afford 3-(6-chloro-1-methyl-1H-benzoimidazol-2-yl)-pyridine-4-carbaldehyde. MS (ESI) m/z 272.0 (M+H).

1. customquenched with saturated aqueous sodium bicarbonate solution
2. extractionIt was extracted with DCM twice
3. dry with materialThe organic layer was dried over sodium sulfate
4. concentrationconcentrated in vacuo