HCID 67500921, compound → N-(1H-imidazol-2-ylmethyl)-N-(4-{[7-(2-thienylmethyl)-2,7-diazaspiro[4.4]non-2-yl]methyl}benzyl)-1H-imidazole-2-carboxamide

HRID 1897640Notes

Reaction equation

HRID 1897640 reaction equation
[CH:1]([C:3]1[CH:23]=[CH:22][C:6]([CH2:7][N:8]([CH2:16][C:17]2[NH:18][CH:19]=[CH:20][N:21]=2)[C:9]([C:11]2[NH:12][CH:13]=[CH:14][N:15]=2)=[O:10])=[CH:5][CH:4]=1)=O.[S:24]1[CH:28]=[CH:27][CH:26]=[C:25]1[CH2:29][N:30]1[CH2:34][CH2:33][C:32]2([CH2:38][CH2:37][NH:36][CH2:35]2)[CH2:31]1>>[NH:21]1[CH:20]=[CH:19][N:18]=[C:17]1[CH2:16][N:8]([CH2:7][C:6]1[CH:22]=[CH:23][C:3]([CH2:1][N:36]2[CH2:37][CH2:38][C:32]3([CH2:33][CH2:34][N:30]([CH2:29][C:25]4[S:24][CH:28]=[CH:27][CH:26]=4)[CH2:31]3)[CH2:35]2)=[CH:4][CH:5]=1)[C:9]([C:11]1[NH:12][CH:13]=[CH:14][N:15]=1)=[O:10]

Participants

3

Reactant 2

HCID 67500921HCID 67500921, compoundHCID 86632126N-(4-formylbenzyl)-N-(1H-imidazol-2-ylmethyl)-1H-imidazole-2-carboxamide

Product 1

HCID 57764679N-(1H-imidazol-2-ylmethyl)-N-(4-{[7-(2-thienylmethyl)-2,7-diazaspiro[4.4]non-2-yl]methyl}benzyl)-1H-imidazole-2-carboxamideYield 54.4%

Procedure

The same operation as in Example 2 was performed, except for using the compound (107 mg) obtained in Example 38 in place of 2-formyl-N,N-dimethyl-1H-imidazole-1-sulfonamide, and 2-(2-thienylmethyl)-2,7-diazaspiro[4.4]nonane (86 mg) in place of benzylamine, to obtain the title compound (97 mg) having the following physical properties.

Sources & evidence

ORD record
ord-b16bc28e1730433cb71c7b4462cdc548
Source dataset
uspto-grants-2013_08
Patent number
US08519124B2

Reaction notes

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