2-(2-Thienylmethyl)-2,7-diazaspiro[4.4]nonane → N-(1H-imidazol-2-ylmethyl)-N-(4-{[7-(2-thienylmethyl)-2,7-diazaspiro[4.4]non-2-yl]methyl}benzyl)-1H-imidazole-2-carboxamide

Participants

Role	Name	HCID	Charge
Reactant	2-(2-Thienylmethyl)-2,7-diazaspiro[4.4]nonane	HCID 67500921	—
Reactant	N-(4-formylbenzyl)-N-(1H-imidazol-2-ylmethyl)-1H-imidazole-2-carboxamide	HCID 86632126	—
Product	N-(1H-imidazol-2-ylmethyl)-N-(4-{[7-(2-thienylmethyl)-2,7-diazaspiro[4.4]non-2-yl]methyl}benzyl)-1H-imidazole-2-carboxamide	HCID 57764679	54.4%

Reaction Steps

The same operation as in Example 2 was performed, except for using the compound (107 mg) obtained in Example 38 in place of 2-formyl-N,N-dimethyl-1H-imidazole-1-sulfonamide, and 2-(2-thienylmethyl)-2,7-diazaspiro[4.4]nonane (86 mg) in place of benzylamine, to obtain the title compound (97 mg) having the following physical properties.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08519124B2
Source dataset	uspto-grants-2013_08
ORD ID	ord-b16bc28e1730433cb71c7b4462cdc548
Source note	uspto-grants-2013_08