反应详情

温度

50 °C

To a solution of 1-bromo-5-fluoro-2-methyl-4-nitrobenzene (Step 1, 1.5 g, 6.4 mmol) in 2-propanol (30 mL) was added cesium carbonate (5.3 g, 16 mmol). The mixture was heated at 50° C. overnight. The mixture was concentrated and partitioned between ethyl acetate and water. The organic layer was concentrated and the residue was purified with silica gel column chromatography with 5% ethyl acetate in hexanes to afford 1-bromo-5-isopropoxy-2-methyl-4-nitrobenzene as a yellow solid.

1. concentrationThe mixture was concentrated
2. custompartitioned between ethyl acetate and water
3. concentrationThe organic layer was concentrated
4. customthe residue was purified with silica gel column chromatography with 5% ethyl acetate in hexanes