Urea → HCID 54035172, compound

Participants

Reaction Conditions

Reaction Steps

To the 3,4-diaminothiophene obtained in Production Example 1 were added 1.1 equivalents of urea and amyl alcohol in an amount equivalent to 10 ml/mmol, and under argon gas atmosphere, a reaction was advanced by refluxing at 130° C. for 5 hours, then amyl alcohol was distilled off and the residue was purified by silica gel column chromatography using an ethyl acetate/hexane solvent, so that 1H-thieno[3,4-d]imidazol-2(3H)-one was obtained. The yield based on 3,4-diaminothiophene was 55%.

Provenance & Evidence