Urea → HCID 54035172, compound

HRID 1897842Notes

Reaction equation

HRID 1897842 reaction equation
[NH2:1][C:2]1[C:6]([NH2:7])=[CH:5][S:4][CH:3]=1.N[C:9](N)=[O:10].C(O)CCCC>>[NH:1]1[C:2]2=[CH:3][S:4][CH:5]=[C:6]2[NH:7][C:9]1=[O:10]

Participants

4

Reactant 3

HCID 1176UreaHCID 62761-PentanolHCID 643216Thiophene-3,4-diamine

Product 1

HCID 54035172HCID 54035172, compound

Conditions

Temperature
130 °C

Procedure

To the 3,4-diaminothiophene obtained in Production Example 1 were added 1.1 equivalents of urea and amyl alcohol in an amount equivalent to 10 ml/mmol, and under argon gas atmosphere, a reaction was advanced by refluxing at 130° C. for 5 hours, then amyl alcohol was distilled off and the residue was purified by silica gel column chromatography using an ethyl acetate/hexane solvent, so that 1H-thieno[3,4-d]imidazol-2(3H)-one was obtained. The yield based on 3,4-diaminothiophene was 55%.

Workup

  1. distillationamyl alcohol was distilled off
  2. customthe residue was purified by silica gel column chromatography

Sources & evidence

ORD record
ord-b46ba77f667f4656819dc998cf0a4a15
Source dataset
uspto-grants-2013_08
Patent number
US08519150B2

Reaction notes

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