Methanol → HCID 131730834, compound

Participants

Reaction Steps

To a mixture of methanol (65 g) and N-methylpyrrolidone (NMP; 65 g) are added BHT (100 mg) and crude pentamycin (20 g; chemical purity: 80.6%; pentamycin content: 80%; imp rrt=0.83:8.0%; imp rrt=1.54:7.0%). The mixture was stirred at room temperature for 5 hours. The crystals are filtered, washed with methanol (2 times 10 ml) and dried under reduced pressure to yield pentamycin-NMP-solvate (17.3 g; chemical purity: 86.9%; pentamycin content: 71%; imp rrt=0.83:5.8%; imp rrt=1.54:5.0%).

Provenance & Evidence