Methanol → HCID 131730834, compound

HRID 1897844Notes

Reaction equation

HRID 1897844 reaction equation
CO.[CH3:3][CH2:4][CH2:5][CH2:6][CH2:7][C@@H:8]([OH:49])[C@H:9]1[C:36](=[O:37])[O:35][C@H:34]([CH3:38])[C@@H:33]([OH:39])[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=[C:23]([CH3:40])[C@@H:22]([OH:41])[C@H:21]([OH:42])[C@H:20]([OH:43])[CH2:19][C@H:18]([OH:44])[CH2:17][C@H:16]([OH:45])[CH2:15][C@H:14]([OH:46])[CH2:13][C@H:12]([OH:47])[CH2:11][C@@H:10]1[OH:48].[CH3:50][N:51]1[CH2:55][CH2:54][CH2:53][C:52]1=[O:56]>>[CH3:3][CH2:4][CH2:5][CH2:6][CH2:7][C@@H:8]([OH:49])[C@H:9]1[C:36](=[O:37])[O:35][C@H:34]([CH3:38])[C@@H:33]([OH:39])[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=[C:23]([CH3:40])[C@@H:22]([OH:41])[C@H:21]([OH:42])[C@H:20]([OH:43])[CH2:19][C@H:18]([OH:44])[CH2:17][C@H:16]([OH:45])[CH2:15][C@H:14]([OH:46])[CH2:13][C@H:12]([OH:47])[CH2:11][C@@H:10]1[OH:48].[CH3:50][N:51]1[CH2:55][CH2:54][CH2:53][C:52]1=[O:56]

Participants

4

Reactant 3

HCID 887MethanolHCID 13387N-methyl-2-pyrrolidoneHCID 52822006834-98-6

Product 1

HCID 131730834HCID 131730834, compoundYield 75.4%

Procedure

To a mixture of methanol (65 g) and N-methylpyrrolidone (NMP; 65 g) are added BHT (100 mg) and crude pentamycin (20 g; chemical purity: 80.6%; pentamycin content: 80%; imp rrt=0.83:8.0%; imp rrt=1.54:7.0%). The mixture was stirred at room temperature for 5 hours. The crystals are filtered, washed with methanol (2 times 10 ml) and dried under reduced pressure to yield pentamycin-NMP-solvate (17.3 g; chemical purity: 86.9%; pentamycin content: 71%; imp rrt=0.83:5.8%; imp rrt=1.54:5.0%).

Workup

  1. filtrationThe crystals are filtered
  2. washwashed with methanol (2 times 10 ml)
  3. customdried under reduced pressure

Sources & evidence

ORD record
ord-205d01ba07b34fb598973b9c7ec414ef
Source dataset
uspto-grants-2013_08
Patent number
US08519162B2

Reaction notes

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