Ethanol → Tert-butyl 4-(2-chloropyrimidin-4-yl)piperazine-1-carboxylate

HRID 189808Notes

Reaction equation

HRID 189808 reaction equation
[C:15]([CH3:16])([CH3:17])([CH3:18])[O:19][C:20](=[O:21])[N:22]1[CH2:23][CH2:24][NH:25][CH2:26][CH2:27]1.[CH3:28][CH2:29][OH:30].[Cl:1][c:2]1[n:3][cH:4][cH:5][c:6]([Cl:8])[n:7]1.[Na+:10].[Na+:9].[O-:11][C:12](=[O:13])[O-:14]>>[Cl:1][c:2]1[n:3][cH:4][cH:5][c:6]([N:25]2[CH2:24][CH2:23][N:22]([C:20]([O:19][C:15]([CH3:16])([CH3:17])[CH3:18])=[O:21])[CH2:27][CH2:26]2)[n:7]1

Participants

6

Reactant 5

HCID 702EthanolHCID 923Sodium ion2×HCID 19660Carbonate IonHCID 775312,4-DichloropyrimidineHCID 143452tert-Butyl piperazine-1-carboxylate

Product 1

HCID 11197306Tert-butyl 4-(2-chloropyrimidin-4-yl)piperazine-1-carboxylate

Sources & evidence

ORD record
ord-0a290182e7b94d1898cd475490d38b71
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Reaction notes

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