3-Amino-2-bromo-5-chloropyridine → HCID 58268115, compound

HRID 1898246Notes

Reaction equation

HRID 1898246 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([S:8](Cl)(=[O:10])=[O:9])=[CH:4][C:3]=1[C:12]([F:15])([F:14])[CH3:13].[Br:16][C:17]1[C:22]([NH2:23])=[CH:21][C:20]([Cl:24])=[CH:19][N:18]=1>N1C=CC=CC=1>[Br:16][C:17]1[C:22]([NH:23][S:8]([C:5]2[CH:6]=[CH:7][C:2]([Cl:1])=[C:3]([C:12]([F:15])([F:14])[CH3:13])[CH:4]=2)(=[O:10])=[O:9])=[CH:21][C:20]([Cl:24])=[CH:19][N:18]=1

Participants

4

Reactant 2

HCID 27696403-Amino-2-bromo-5-chloropyridineHCID 58268227HCID 58268227, compound

Product 1

HCID 58268115HCID 58268115, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

Prepared from 377 mg (1.37 mmol) of 4-chloro-3-(1,1-difluoro-ethyl)-benzenesulfonyl chloride and 270 mg (1.30 mmol) of 2-bromo-5-chloro-pyridin-3-ylamine in 2 mL pyridine using procedure x. Yield: 460 mg of a white solid. LC-MSD, m/z for C13H9BrCl2F2N2O2S [M+H]+=444.8, 446.8, 448.8.

Sources & evidence

ORD record
ord-456cd2a6940a48229ecc4a446e5f18ed
Source dataset
uspto-grants-2013_08
Patent number
US08519135B2

Reaction notes

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