4-Methyl-3-(trifluoromethyl)benzene-1-sulfonyl chloride → N-(2-cyano-5-methyl-pyridin-3-yl)-4-methyl-3-trifluoromethyl-benzenesulfonamide

HRID 1898247Notes

Reaction equation

HRID 1898247 reaction equation
[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([S:8](Cl)(=[O:10])=[O:9])=[CH:4][C:3]=1[C:12]([F:15])([F:14])[F:13].[NH2:16][C:17]1[C:18]([C:24]#[N:25])=[N:19][CH:20]=[C:21]([CH3:23])[CH:22]=1>N1C=CC=CC=1>[C:24]([C:18]1[C:17]([NH:16][S:8]([C:5]2[CH:6]=[CH:7][C:2]([CH3:1])=[C:3]([C:12]([F:15])([F:14])[F:13])[CH:4]=2)(=[O:10])=[O:9])=[CH:22][C:21]([CH3:23])=[CH:20][N:19]=1)#[N:25]

Participants

4

Reactant 2

HCID 189565564-Methyl-3-(trifluoromethyl)benzene-1-sulfonyl chlorideHCID 533953753-Amino-5-methylpyridine-2-carbonitrile

Product 1

HCID 57870821N-(2-cyano-5-methyl-pyridin-3-yl)-4-methyl-3-trifluoromethyl-benzenesulfonamide

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

Prepared from 2.92 g (11.3 mmol) of 4-methyl-3-trifluoromethyl-benzenesulfonyl chloride and 1.25 g (9.41 mmol) of 3-amino-5-methyl-pyridine-2-carbonitrile in 4 mL pyridine using procedure x. Yield: 1.13 g of a white solid. LC-MSD, m/z for C15H12F3N3O2S [M+H]+=356.0

Sources & evidence

ORD record
ord-9ef16bc91d7a4c5c857c2a6145598baf
Source dataset
uspto-grants-2013_08
Patent number
US08519135B2

Reaction notes

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