HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Methyl-3-(trifluoromethyl)benzene-1-sulfonyl chloride → N-(2-cyano-5-methyl-pyridin-3-yl)-4-methyl-3-trifluoromethyl-benzenesulfonamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Methyl-3-(trifluoromethyl)benzene-1-sulfonyl chloride | HCID 18956556 | — |
| Reactant | 3-Amino-5-methylpyridine-2-carbonitrile | HCID 53395375 | — |
| Solvent | Pyridine | HCID 1049 | — |
| Product | N-(2-cyano-5-methyl-pyridin-3-yl)-4-methyl-3-trifluoromethyl-benzenesulfonamide | HCID 57870821 | — |
Reaction Steps
Prepared from 2.92 g (11.3 mmol) of 4-methyl-3-trifluoromethyl-benzenesulfonyl chloride and 1.25 g (9.41 mmol) of 3-amino-5-methyl-pyridine-2-carbonitrile in 4 mL pyridine using procedure x. Yield: 1.13 g of a white solid. LC-MSD, m/z for C15H12F3N3O2S [M+H]+=356.0
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08519135B2 |
| Source dataset | uspto-grants-2013_08 |
| ORD ID | ord-9ef16bc91d7a4c5c857c2a6145598baf |
| Source note | uspto-grants-2013_08 |