Sodium Hydroxide → HCID 86664689, compound

HRID 1898298Notes

Reaction equation

HRID 1898298 reaction equation
[Cl:1][C:2]1[CH:3]=[N:4][CH:5]=[C:6]([Cl:27])[C:7]=1[NH:8][C:9]1[S:10][C:11]2[C:17]3[CH2:18][C:19]([CH3:22])([CH3:21])[O:20][C:16]=3[C:15]([C:23]([O:25]C)=[O:24])=[CH:14][C:12]=2[N:13]=1.[OH-].[Na+]>CO>[Cl:1][C:2]1[CH:3]=[N:4][CH:5]=[C:6]([Cl:27])[C:7]=1[NH:8][C:9]1[S:10][C:11]2[C:17]3[CH2:18][C:19]([CH3:22])([CH3:21])[O:20][C:16]=3[C:15]([C:23]([OH:25])=[O:24])=[CH:14][C:12]=2[N:13]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 86664690HCID 86664690, compound

Product 1

HCID 86664689HCID 86664689, compoundYield 64.8%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

The title compound was prepared following the procedure described for step-2 of intermediate-3 using methyl 2-[(3,5-dichloropyridin-4-yl)amino]-7,7-dimethyl-7,8-dihydrofuro[2,3-g][1,3]benzothiazole-5-carboxylate (0.080 g, 0.188 mmol), methanol (2.0 mL) and (50%) aqueous solution of sodium hydroxide (0.200 g, 5.00 mmol) to afford 0.050 g of the desired product. 1HNMR (DMSO-d6): δ 1.43 (s, 6H), 2.98 (s, 2H), 7.37 (s, 1H), 7.30 (s, 1H), 8.61 (m, 2H), 12-13 (s, 1H); MS [M+H]+: 424.18.

Workup

  1. customThe title compound was prepared

Sources & evidence

ORD record
ord-ace1f13942b74484884201e0e7eadba7
Source dataset
uspto-grants-2013_08
Patent number
US08519149B2

Reaction notes

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