Thiophosgene → 2-Chloro-6-fluorophenylisothiocyanate

HRID 1898299노트

반응식

[Cl:1][C:2]1[CH:8]=[CH:7][CH:6]=[C:5]([F:9])[C:3]=1[NH2:4].[C:10](Cl)(Cl)=[S:11].C(N(C(C)C)C(C)C)C>>[Cl:1][C:2]1[CH:8]=[CH:7][CH:6]=[C:5]([F:9])[C:3]=1[N:4]=[C:10]=[S:11]

참가 물질

반응물 3

HCID 10040Thiophosgene

HCID 81531Diisopropylethylamine

HCID 27342052-Chloro-6-fluoroaniline

생성물 1

HCID 265991402-Chloro-6-fluorophenylisothiocyanate수율 27.5%

실험 절차

The title compound was prepared following the procedure described for intermediate-2 using 2-chloro-6-fluoro aniline (3.0 g, 19.35 mmol), thiophosgene (5.01 g, 43.47 mmol) and N-ethyl di-isopropyl amine (8.0 g, 64.00 mmol) to afford 1.0 g of the desired product. 1HNMR (DMSO-d6): δ 7.26 (m, 2H), 7.06 (t, J=9.6 Hz, 1H).

후처리

customThe title compound was prepared

출처 및 근거

ORD 기록: ord-11a536e4c23740aba11eac6e8170db41
출처 데이터셋: uspto-grants-2013_08
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08519149B2

반응 노트

불러오는 중…