Hydrogen Peroxide → HCID 178507977, compound

HRID 1898318Notes

Reaction equation

HRID 1898318 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([F:9])[C:5]([NH2:8])=[N:6][CH:7]=1.[OH:10]O>C(O)(=O)C>[NH2:8][C:5]1[C:4]([F:9])=[CH:3][C:2]([Cl:1])=[CH:7][N+:6]=1[O-:10]

Participants

4

Reactant 2

HCID 784Hydrogen PeroxideHCID 116654332-Amino-5-chloro-3-fluoropyridine

Product 1

HCID 178507977HCID 178507977, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

The title compound was prepared following the procedure described for Intermediate-40 using 5-chloro-3-fluoropyridin-2-amine (0.500 g, 3.42 mmol), acetic acid (5.0 mL) and 50% hydrogen peroxide (2.0 mL) to afford 0.450 g of the desired product. 1HNMR (DMSO-d6): δ 7.14 (s, 2H), 7.55 (d, J=10.8 Hz, 1H), 8.25 (s, 1H).

Workup

  1. customThe title compound was prepared

Sources & evidence

ORD record
ord-415778cc06ff4b3ebc63396785a841f4
Source dataset
uspto-grants-2013_08
Patent number
US08519149B2

Reaction notes

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