Citric Acid → HCID 178422761, compound

HRID 1898414Notes

Reaction equation

HRID 1898414 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([F:8])[C:3]=1[NH:9][C:10]1[NH:11][C:12]2[C:18]3[CH2:19][C:20]([CH3:23])([CH3:22])[O:21][C:17]=3[C:16]([C:24]([NH:26][C:27]3[CH:32]=[CH:31][C:30]([C:33]([F:36])([F:35])[F:34])=[CH:29][CH:28]=3)=[O:25])=[CH:15][C:13]=2[N:14]=1.[C:37]([OH:49])(=[O:48])[CH2:38][C:39]([CH2:44][C:45]([OH:47])=[O:46])([C:41]([OH:43])=[O:42])[OH:40]>CC(C)=O>[OH:40][C:39]([C:41]([OH:43])=[O:42])([CH2:44][C:45]([OH:47])=[O:46])[CH2:38][C:37]([OH:49])=[O:48].[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([F:8])[C:3]=1[NH:9][C:10]1[NH:11][C:12]2[C:18]3[CH2:19][C:20]([CH3:22])([CH3:23])[O:21][C:17]=3[C:16]([C:24]([NH:26][C:27]3[CH:28]=[CH:29][C:30]([C:33]([F:35])([F:36])[F:34])=[CH:31][CH:32]=3)=[O:25])=[CH:15][C:13]=2[N:14]=1

Participants

4

Reactant 2

HCID 311Citric AcidHCID 178422755HCID 178422755, compound

Product 1

HCID 178422761HCID 178422761, compound

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

To a solution of 2-[(2-chloro-6-fluorophenyl)amino]-7,7-dimethyl-N-[4-(trifluoromethyl)phenyl]-7,8-dihydro-1H-furo[3,2-e]benzimidazole-5-carboxamide (Example-107, 0.100 g) in acetone was added citric acid. The reaction mass was refluxed for 3 h. The reaction mass was filtered and the obtained residue was washed with DEE to afford 0.100 g of the desired product.

Workup

  1. temperatureThe reaction mass was refluxed for 3 h
  2. filtrationThe reaction mass was filtered
  3. washthe obtained residue was washed with DEE

Sources & evidence

ORD record
ord-5256f3e79c88407bad56c4e8bee5abe8
Source dataset
uspto-grants-2013_08
Patent number
US08519149B2

Reaction notes

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