Methanesulfonic Acid → HCID 178422783, compound

HRID 1898472Notes

Reaction equation

HRID 1898472 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([F:8])[C:3]=1[NH:9][C:10]1[NH:11][C:12]2[C:18]3[CH2:19][C:20]([CH3:23])([CH3:22])[O:21][C:17]=3[C:16]([C:24]([NH:26][C:27]3[CH:32]=[CH:31][C:30]([F:33])=[C:29]([C:34]([F:37])([F:36])[F:35])[CH:28]=3)=[O:25])=[CH:15][C:13]=2[N:14]=1.[CH3:38][S:39]([OH:42])(=[O:41])=[O:40]>CC(C)=O>[CH3:38][S:39]([OH:42])(=[O:41])=[O:40].[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([F:8])[C:3]=1[NH:9][C:10]1[NH:11][C:12]2[C:18]3[CH2:19][C:20]([CH3:23])([CH3:22])[O:21][C:17]=3[C:16]([C:24]([NH:26][C:27]3[CH:32]=[CH:31][C:30]([F:33])=[C:29]([C:34]([F:37])([F:36])[F:35])[CH:28]=3)=[O:25])=[CH:15][C:13]=2[N:14]=1

Participants

4

Reactant 2

HCID 6395Methanesulfonic AcidHCID 178422781HCID 178422781, compound

Product 1

HCID 178422783HCID 178422783, compound

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

The title compound was prepared following the procedure described for Example-169 by using 2-[(2-chloro-6-fluorophenyl)amino]-N-[4-fluoro-3-(trifluoromethyl)phenyl]-7,7-dimethyl-7,8-dihydro-1H-furo[3,2-e]benzimidazole-5-carboxamide (Example-104, 0.100 g), acetone, methanesulphonic acid to afford 0.071 g of the desired product. 1HNMR (DMSO-d6): δ 1.58 (s, 6H), 2.34 (s, 3H), 3.21 (s, 2H), 7.51-7.66 (m, 5H), 7.89 (m, 1H), 8.30 (m, 1H), 9.99 (s, 1H), 11.20 (br s, 1H), 13.20 (br s, 2H).

Workup

  1. customThe title compound was prepared

Sources & evidence

ORD record
ord-cdce496fbb9d425b9f06dbb5fe7b5c1e
Source dataset
uspto-grants-2013_08
Patent number
US08519149B2

Reaction notes

Loading…