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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1898473Generated: November 2, 2026

HCID 178422778, compound → HCID 178422779, compound

https://huagongshe.com/reaction/1898473

Reaction equation

Participants

RoleNameHCIDCharge
ReactantHCID 178422778HCID 178422778—
SolventTetrahydrofuranHCID 8028—
ProductHydrochloric AcidHCID 313—
ProductHCID 178422779HCID 178422779160.4%

Reaction Steps

The title compound was prepared following the procedure described for Example-146 by using 2-((3,5-dichloropyridin-4-yl)amino)-N-(4-fluoro-3-(trifluoromethyl)phenyl)-7,7-dimethyl-7,8-dihydro-1H-benzofuro[4,5-d]imidazole-5-carboxamide (Example-196, 0.100 g), THF, conc.HCl to afford 0.057 g of the desired product. 1HNMR (DMSO-d6): δ 1.58 (s, 6H), 3.11 (s, 2H), 7.38 (s, 1H), 7.52 (t, J=5.4 Hz, 1H), 7.68 (m, 1H), 8.30 (d, J=10.2 Hz, 1H), 8.59 (s, 2H), 9.90 (s, 1H), 12.00 (br s, 4H).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08519149B2
Source datasetuspto-grants-2013_08
ORD IDord-869e81b2e9ca401ea48560b2c3fc38e4
Source noteuspto-grants-2013_08