HuagongsheHuagongshe Chemistry Print Report · For research reference only
HCID 178422778, compound → HCID 178422779, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | HCID 178422778 | HCID 178422778 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | Hydrochloric Acid | HCID 313 | — |
| Product | HCID 178422779 | HCID 178422779 | 160.4% |
Reaction Steps
The title compound was prepared following the procedure described for Example-146 by using 2-((3,5-dichloropyridin-4-yl)amino)-N-(4-fluoro-3-(trifluoromethyl)phenyl)-7,7-dimethyl-7,8-dihydro-1H-benzofuro[4,5-d]imidazole-5-carboxamide (Example-196, 0.100 g), THF, conc.HCl to afford 0.057 g of the desired product. 1HNMR (DMSO-d6): δ 1.58 (s, 6H), 3.11 (s, 2H), 7.38 (s, 1H), 7.52 (t, J=5.4 Hz, 1H), 7.68 (m, 1H), 8.30 (d, J=10.2 Hz, 1H), 8.59 (s, 2H), 9.90 (s, 1H), 12.00 (br s, 4H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08519149B2 |
| Source dataset | uspto-grants-2013_08 |
| ORD ID | ord-869e81b2e9ca401ea48560b2c3fc38e4 |
| Source note | uspto-grants-2013_08 |