HCID 178422778, compound → HCID 178422779, compound

HRID 1898473Notes

Reaction equation

HRID 1898473 reaction equation
[Cl:1][C:2]1[CH:3]=[N:4][CH:5]=[C:6]([Cl:37])[C:7]=1[NH:8][C:9]1[NH:13][C:12]2[C:14]3[CH2:15][C:16]([CH3:36])([CH3:35])[O:17][C:18]=3[C:19]([C:21]([NH:23][C:24]3[CH:29]=[CH:28][C:27]([F:30])=[C:26]([C:31]([F:34])([F:33])[F:32])[CH:25]=3)=[O:22])=[CH:20][C:11]=2[N:10]=1>C1COCC1>[ClH:1].[ClH:1].[Cl:1][C:2]1[CH:3]=[N:4][CH:5]=[C:6]([Cl:37])[C:7]=1[NH:8][C:9]1[NH:13][C:12]2[C:14]3[CH2:15][C:16]([CH3:35])([CH3:36])[O:17][C:18]=3[C:19]([C:21]([NH:23][C:24]3[CH:29]=[CH:28][C:27]([F:30])=[C:26]([C:31]([F:34])([F:32])[F:33])[CH:25]=3)=[O:22])=[CH:20][C:11]=2[N:10]=1

Participants

4

Reactant 1

HCID 178422778HCID 178422778, compound

Product 2

HCID 313Hydrochloric AcidHCID 178422779HCID 178422779, compoundYield 160.4%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

The title compound was prepared following the procedure described for Example-146 by using 2-((3,5-dichloropyridin-4-yl)amino)-N-(4-fluoro-3-(trifluoromethyl)phenyl)-7,7-dimethyl-7,8-dihydro-1H-benzofuro[4,5-d]imidazole-5-carboxamide (Example-196, 0.100 g), THF, conc.HCl to afford 0.057 g of the desired product. 1HNMR (DMSO-d6): δ 1.58 (s, 6H), 3.11 (s, 2H), 7.38 (s, 1H), 7.52 (t, J=5.4 Hz, 1H), 7.68 (m, 1H), 8.30 (d, J=10.2 Hz, 1H), 8.59 (s, 2H), 9.90 (s, 1H), 12.00 (br s, 4H).

Workup

  1. customThe title compound was prepared

Sources & evidence

ORD record
ord-869e81b2e9ca401ea48560b2c3fc38e4
Source dataset
uspto-grants-2013_08
Patent number
US08519149B2

Reaction notes

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