反应详情

In a 10 mL round-bottomed flask, (R)-tert-butyl 3,3-dimethyl-1-oxo-1-(pyrrolidin-1-yl)butan-2-ylcarbamate (0.160 g, 0.56 mmol) was dissolved in 1.0 M hydrogen chloride solution in MeOH (3.6 ml, 3.6 mmol). The reaction mixture was stirred at room temperature overnight the concentrated to afford 140 mg of (R)-2-amino-3,3-dimethyl-1-(pyrrolidin-1-yl)butan-1-one hydrochloride as a hydroscopic off-white foam which was used without further purification.

1. concentrationconcentrated