Hydrochloric Acid → 3-Methylpyrrolidine-3-carbonitrile hydrochloride

Participants

Reaction Steps

A sample of tert-butyl 3-cyano-3-methylpyrrolidine-1-carboxylate (0.50 g, 2.38 mmol) was dissolved in 1.0 M HCl in MeOH (12 mL). The reaction mixture was stirred at room temperature overnight then concentrated to afford 0.38 g of 3-methylpyrrolidine-3-carbonitrile hydrochloride as a hydroscopic white foamy solid which was used without further purification.

Provenance & Evidence