Hydrochloric Acid → 3-Methylpyrrolidine-3-carbonitrile hydrochloride

HRID 1898502Notes

Reaction equation

HRID 1898502 reaction equation
[C:1]([C:3]1([CH3:15])[CH2:7][CH2:6][N:5](C(OC(C)(C)C)=O)[CH2:4]1)#[N:2].[ClH:16]>CO>[ClH:16].[CH3:15][C:3]1([C:1]#[N:2])[CH2:7][CH2:6][NH:5][CH2:4]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 57516600Tert-butyl 3-cyano-3-methylpyrrolidine-1-carboxylate

Product 1

HCID 575166013-Methylpyrrolidine-3-carbonitrile hydrochloride

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A sample of tert-butyl 3-cyano-3-methylpyrrolidine-1-carboxylate (0.50 g, 2.38 mmol) was dissolved in 1.0 M HCl in MeOH (12 mL). The reaction mixture was stirred at room temperature overnight then concentrated to afford 0.38 g of 3-methylpyrrolidine-3-carbonitrile hydrochloride as a hydroscopic white foamy solid which was used without further purification.

Workup

  1. concentrationthen concentrated

Sources & evidence

ORD record
ord-91799b80288f4b9495ca450c1c7f39fd
Source dataset
uspto-grants-2013_08
Patent number
US08518945B2

Reaction notes

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