反应详情

To a solution of tert-butyl (2R)-1-(3-cyano-3-fluoropyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-ylcarbamate (234 mg, 0.72 mmol) in CH2Cl2 (5 mL) was added TFA (2.0 mL, 26.0 mmol). The reaction mixture was stirred at room temperature for 3 h then concentrated and dried under high vacuum to provide 1-((R)-2-amino-3,3-dimethylbutanoyl)-3-fluoropyrrolidine-3-carbonitrile trifluoroacetate as a pale yellow oil which was used without further purification.

1. concentrationthen concentrated
2. customdried under high vacuum