HuagongsheHuagongshe Chemistry Print Report · For research reference only
Isobutylamine → 6-hydroxy-N-isobutyl-2,5,7,8-tetramethylchroman-2-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Isobutylamine | HCID 6558 | — |
| Reactant | Trolox | HCID 40634 | — |
| Reactant | 1,1'-Carbonyldiimidazole | HCID 68263 | — |
| Product | 6-hydroxy-N-isobutyl-2,5,7,8-tetramethylchroman-2-carboxamide | HCID 67263059 | 75% |
Reaction Steps
Following the amide coupling procedure described in protocol A, 510 mg 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid (2.04 mmol), 357 mg CDI (2.20 mmol) and 161 mg isobutylamine (2.2 mmol) produced 467 mg of 6-hydroxy-N-isobutyl-2,5,7,8-tetramethylchroman-2-carboxamide as an off-white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08519001B2 |
| Source dataset | uspto-grants-2013_08 |
| ORD ID | ord-afb97ff7c7dc48f69e73c85b76ab3560 |
| Source note | uspto-grants-2013_08 |