4-Amino-1-butanol → HCID 67262901, compound

HRID 1898699Notes

Reaction equation

HRID 1898699 reaction equation
[OH:1][C:2]1[C:3]([CH3:18])=[C:4]2[C:9](=[C:10]([CH3:13])[C:11]=1[CH3:12])[O:8][C:7]([CH3:17])([C:14]([OH:16])=O)[CH2:6][CH2:5]2.C1N=CN(C(N2C=NC=C2)=O)C=1.[NH2:31][CH2:32][CH2:33][CH2:34][CH2:35][OH:36]>>[OH:1][C:2]1[C:3]([CH3:18])=[C:4]2[C:9](=[C:10]([CH3:13])[C:11]=1[CH3:12])[O:8][C:7]([CH3:17])([C:14]([NH:31][CH2:32][CH2:33][CH2:34][CH2:35][OH:36])=[O:16])[CH2:6][CH2:5]2

Participants

4

Reactant 3

HCID 258684-Amino-1-butanolHCID 40634TroloxHCID 682631,1'-Carbonyldiimidazole

Product 1

HCID 67262901HCID 67262901, compoundYield 74.8%

Procedure

Following the amide coupling procedure described in protocol A, 507 mg 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid (2.03 mmol), 356 mg CDI (2.20 mmol) and 196 mg 4-aminobutanol (2.20 mmol) produced 488 mg of 6-hydroxy-N-(4-hydroxybutyl)-2,5,7,8-tetramethylchroman-2-carboxamide as a white powder.

Sources & evidence

ORD record
ord-e23690a6a33f401bad8e6cb274efd429
Source dataset
uspto-grants-2013_08
Patent number
US08519001B2

Reaction notes

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