Hydrochloric Acid → HCID 67769852, compound

Participants

Reaction Steps

2.5 ml of a 6.6 molar solution of HCl in ether were added dropwise to a solution of 6.55 g (15 mmol) of 4-amino-2-(4,4-dimethyl-2-oxo-1-imidazolidinyl)pyrimidine-5-carboxylic acid N-isopropyl-N-(3-trifluoromethylphenyl)amide prepared as in Example 3 in 35 ml of acetone at room temperature, and the resulting suspension was stirred at room temperature for 2 hours. The crystals were then filtered off with suction, washed with acetone and dried in vacuo at 100° for 10 hours. 6.84 g (=96.5% yield) of 4-amino-2-(4,4-dimethyl-2-oxo-1-imidazolidinyl)pyrimidine-5-carboxylic acid N-isopropyl-N-(3-trifluoromethylphenyl)amide hydrochloride were obtained, melting point 279°-280° (decomposition).

Provenance & Evidence