Hydrochloric Acid → HCID 67769852, compound

HRID 1898914Notes

Reaction equation

HRID 1898914 reaction equation
[ClH:1].[CH:2]([N:5]([C:23]1[CH:28]=[CH:27][CH:26]=[C:25]([C:29]([F:32])([F:31])[F:30])[CH:24]=1)[C:6]([C:8]1[C:9]([NH2:22])=[N:10][C:11]([N:14]2[CH2:18][C:17]([CH3:20])([CH3:19])[NH:16][C:15]2=[O:21])=[N:12][CH:13]=1)=[O:7])([CH3:4])[CH3:3]>CCOCC.CC(C)=O>[ClH:1].[CH:2]([N:5]([C:23]1[CH:28]=[CH:27][CH:26]=[C:25]([C:29]([F:30])([F:31])[F:32])[CH:24]=1)[C:6]([C:8]1[C:9]([NH2:22])=[N:10][C:11]([N:14]2[CH2:18][C:17]([CH3:20])([CH3:19])[NH:16][C:15]2=[O:21])=[N:12][CH:13]=1)=[O:7])([CH3:4])[CH3:3]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 53973934HCID 53973934, compound

Product 1

HCID 67769852HCID 67769852, compoundYield 96.5%

Reagents, catalysts & solvents 2

HCID 180AcetoneSolventHCID 3283Diethyl EtherSolvent

Procedure

2.5 ml of a 6.6 molar solution of HCl in ether were added dropwise to a solution of 6.55 g (15 mmol) of 4-amino-2-(4,4-dimethyl-2-oxo-1-imidazolidinyl)pyrimidine-5-carboxylic acid N-isopropyl-N-(3-trifluoromethylphenyl)amide prepared as in Example 3 in 35 ml of acetone at room temperature, and the resulting suspension was stirred at room temperature for 2 hours. The crystals were then filtered off with suction, washed with acetone and dried in vacuo at 100° for 10 hours. 6.84 g (=96.5% yield) of 4-amino-2-(4,4-dimethyl-2-oxo-1-imidazolidinyl)pyrimidine-5-carboxylic acid N-isopropyl-N-(3-trifluoromethylphenyl)amide hydrochloride were obtained, melting point 279°-280° (decomposition).

Workup

  1. filtrationThe crystals were then filtered off with suction
  2. washwashed with acetone
  3. customdried in vacuo at 100° for 10 hours

Sources & evidence

ORD record
ord-77decd7271ab40b2bd22f98f16173c49
Source dataset
uspto-grants-1996_11
Patent number
US05571816

Reaction notes

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