HCID 178449491, compound → HCID 54432118, compound

HRID 1898915Notes

Reaction equation

HRID 1898915 reaction equation
[C:1]([C:3]([C:14](=[O:30])[N:15]([CH2:26][CH2:27][CH2:28][CH3:29])[C:16]1[CH:21]=[CH:20][CH:19]=[C:18]([C:22]([F:25])([F:24])[F:23])[CH:17]=1)=[CH:4][NH:5][C:6](=[NH:13])[N:7]1[CH2:11][CH2:10][NH:9][C:8]1=[O:12])#[N:2]>C(O)(=O)C>[CH2:26]([N:15]([C:16]1[CH:21]=[CH:20][CH:19]=[C:18]([C:22]([F:23])([F:24])[F:25])[CH:17]=1)[C:14]([C:3]1[C:1]([NH2:2])=[N:13][C:6]([N:7]2[CH2:11][CH2:10][NH:9][C:8]2=[O:12])=[N:5][CH:4]=1)=[O:30])[CH2:27][CH2:28][CH3:29]

Participants

3

Reactant 1

HCID 178449491HCID 178449491, compound2×

Product 1

HCID 54432118HCID 54432118, compoundYield 47.3%

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

As in Example 51, 1.80 g (4.26 mmol) of 1-cyano-1-[N-butyl-N-(3-trifluoromethylphenyl)carbamoyl]-2-[imino(2-oxo-1-imidazolidinyl)methylamino]ethene (compound II, R1, R2, R3, R5, R6 =H; R4 =n-C4H9) and 4.7 ml of glacial acetic acid were stirred at 60° for 4 hours and subsequently worked up. 0.85 g (=47.3% yield) of pure 4-amino-2-(2-oxo-1-imidazolidinyl)pyrimidine-5-carboxylic acid N-butyl-N-(3-trifluoromethylphenyl)amide was obtained, melting point 234°-235°.

Sources & evidence

ORD record
ord-c8f2821c06ce4447beb51d25d1880719
Source dataset
uspto-grants-1996_11
Patent number
US05571816

Reaction notes

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