反应详情

As in Example 118 and starting from 4.52 g (10 mmol) of a compound II (R1, R2 =CH3 ; R3, R5, R6 =H; R4 =CH3OCH2CH2), 360 mg of anhydrous oxalic acid and 7 ml of glacial acetic acid, 2.65 g (=58.6% yield) of pure 4-amino-2-(4,4-dimethyl-2-oxo-1-imidazolidinyl)-pyrimidine-5-carboxylic acid N-(2-methoxyethyl)-N-(3-trifluoromethylphenyl)amide were obtained, melting point 192°-93°.