HuagongsheHuagongshe Chemistry Print Report · For research reference only
Oxalic Acid → 4-amino-2-(4,4-dimethyl-2-oxo-1-imidazolidinyl)-pyrimidine-5-carboxylic acid N-(2-methoxyethyl)-N-(3-trifluoromethylphenyl)amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Oxalic Acid | HCID 971 | — |
| Reactant | HCID 178428592 | HCID 178428592 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | 4-amino-2-(4,4-dimethyl-2-oxo-1-imidazolidinyl)-pyrimidine-5-carboxylic acid N-(2-methoxyethyl)-N-(3-trifluoromethylphenyl)amide | HCID 54572741 | 146.5% |
Reaction Steps
As in Example 118 and starting from 4.52 g (10 mmol) of a compound II (R1, R2 =CH3 ; R3, R5, R6 =H; R4 =CH3OCH2CH2), 360 mg of anhydrous oxalic acid and 7 ml of glacial acetic acid, 2.65 g (=58.6% yield) of pure 4-amino-2-(4,4-dimethyl-2-oxo-1-imidazolidinyl)-pyrimidine-5-carboxylic acid N-(2-methoxyethyl)-N-(3-trifluoromethylphenyl)amide were obtained, melting point 192°-93°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05571816 |
| Source dataset | uspto-grants-1996_11 |
| ORD ID | ord-9db74cc38b154f73ba022bba32f9cec3 |
| Source note | uspto-grants-1996_11 |