Methyl Thioglycolate → HCID 54257311, compound

HRID 1898947Notes

Reaction equation

HRID 1898947 reaction equation
[CH3:1][C:2]1[CH:16]=[CH:15][C:5]([CH:6](O)[C:7]2[CH:12]=[CH:11][C:10]([CH3:13])=[CH:9][CH:8]=2)=[CH:4][CH:3]=1.[C:17]([O:21][CH3:22])(=[O:20])[CH2:18][SH:19]>>[CH3:1][C:2]1[CH:16]=[CH:15][C:5]([CH:6]([C:7]2[CH:12]=[CH:11][C:10]([CH3:13])=[CH:9][CH:8]=2)[S:19][CH2:18][C:17]([O:21][CH3:22])=[O:20])=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 16907Methyl ThioglycolateHCID 2793564,4'-Dimethylbenzhydrol

Product 1

HCID 54257311HCID 54257311, compoundYield 73%

Procedure

Following the procedure of Example 4, 4,4'-dimethylbenzhydrol, synthesized in accordance with M. R. Pavia, et. al. in J. Med. Chem. 35, 4238 (1992), is reacted with methyl thioglycolate for 18 hours at room temperature. Chromatography on silica gel, eluting with 10% ethyl acetate in hexane, gives methyl [[bis-(4-methylphenyl)methyl]thio]acetate as a colorless oil in 73% yield.

Workup

  1. customsynthesized in accordance with M
  2. washChromatography on silica gel, eluting with 10% ethyl acetate in hexane

Sources & evidence

ORD record
ord-b1146997290c45759aba53f5d4e4cc5d
Source dataset
uspto-grants-1996_11
Patent number
US05571825

Reaction notes

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