反应详情

Following the procedure of Example 4, 2,2'-dichlorobenzhydrol, synthesized in accordance with C. W. N. Cumper, et. al. in J. C. S. Perkins Trans. II (1), 106 (1972)] is reacted with methyl thioglycolate for 4 hours at 50°-60° C. Chromatography on silica gel, eluting with a gradient of 5% ethyl acetate in hexane to 10% ethyl acetate in hexane, gives methyl [[bis-(2-chlorophenyl)methyl]thio]acetate as a white solid in 23% yield: melting point 90°-92° C.

1. customsynthesized in accordance with C
2. washChromatography on silica gel, eluting with a gradient of 5% ethyl acetate in hexane to 10% ethyl acetate in hexane