HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → 2-Chloro-3-cyclopropylmethyloxy-6-nitro toluene
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | Bromomethylcyclopropane | HCID 81503 | — |
| Reactant | 2-Chloro-3-methyl-4-nitrophenol | HCID 13147355 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 2-Chloro-3-cyclopropylmethyloxy-6-nitro toluene | HCID 23373109 | 93.4% |
Reaction Conditions
| Temperature | 100 °C |
|---|
Reaction Steps
2-Chloro-3-methyl-4-nitrophenol (2.71 g) was reacted with bromomethylcyclopropane (3.89 g) in dry DMF (30 ml) in the presence of potassium carbonate (3.99 g), heating the mixture at 100° C. overnight. The DMF was evaporated in vacuo, and the residue was partitioned between 2M HCl and ethyl acetate. The organic extracts were combined and dried (MgSO4) and evaporated to give 2-chloro-3-cyclopropylmethyloxy-6-nitro toluene (3.26 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05571833 |
| Source dataset | uspto-grants-1996_11 |
| ORD ID | ord-2d224f9831954103ac20201731685567 |
| Source note | uspto-grants-1996_11 |