反应详情

温度

100 °C

2-Chloro-3-methyl-4-nitrophenol (2.71 g) was reacted with bromomethylcyclopropane (3.89 g) in dry DMF (30 ml) in the presence of potassium carbonate (3.99 g), heating the mixture at 100° C. overnight. The DMF was evaporated in vacuo, and the residue was partitioned between 2M HCl and ethyl acetate. The organic extracts were combined and dried (MgSO4) and evaporated to give 2-chloro-3-cyclopropylmethyloxy-6-nitro toluene (3.26 g).

1. customThe DMF was evaporated in vacuo
2. customthe residue was partitioned between 2M HCl and ethyl acetate
3. dry with materialdried (MgSO4)
4. customevaporated