Dimethylformamide → HCID 54230893, compound

Participants

Reaction Steps

A mixture of phosphorus oxychloride (3.2 ml) and N,N-dimethylformamide (3.4 ml) in dichloroethane (25 ml) was stirred at ambient temperature for 1 hour and 2',4'-difluoro-2-[4-(methylthio)phenyl]acetophenone (6.2 g) was added thereto. The mixture was refluxed for 8 hours, washed with water twice, dried and evaporated to give 3-chloro-3-(2,4-difluorophenyl)-2-[4(methylthio)phenyl]propenal as a solid.

Provenance & Evidence