Dimethylformamide → HCID 54230893, compound

HRID 1899073Notes

Reaction equation

HRID 1899073 reaction equation
P(Cl)(Cl)([Cl:3])=O.CN(C)[CH:8]=[O:9].[F:11][C:12]1[CH:17]=[C:16]([F:18])[CH:15]=[CH:14][C:13]=1[C:19](=O)[CH2:20][C:21]1[CH:26]=[CH:25][C:24]([S:27][CH3:28])=[CH:23][CH:22]=1>ClC(Cl)C>[Cl:3][C:19]([C:13]1[CH:14]=[CH:15][C:16]([F:18])=[CH:17][C:12]=1[F:11])=[C:20]([C:21]1[CH:26]=[CH:25][C:24]([S:27][CH3:28])=[CH:23][CH:22]=1)[CH:8]=[O:9]

Participants

5

Reactant 3

HCID 6228DimethylformamideHCID 24813Phosphorus oxychlorideHCID 23372840HCID 23372840, compound

Product 1

HCID 54230893HCID 54230893, compound

Reagents, catalysts & solvents 1

HCID 63651,1-DichloroethaneSolvent

Procedure

A mixture of phosphorus oxychloride (3.2 ml) and N,N-dimethylformamide (3.4 ml) in dichloroethane (25 ml) was stirred at ambient temperature for 1 hour and 2',4'-difluoro-2-[4-(methylthio)phenyl]acetophenone (6.2 g) was added thereto. The mixture was refluxed for 8 hours, washed with water twice, dried and evaporated to give 3-chloro-3-(2,4-difluorophenyl)-2-[4(methylthio)phenyl]propenal as a solid.

Workup

  1. temperatureThe mixture was refluxed for 8 hours
  2. washwashed with water twice
  3. customdried
  4. customevaporated

Sources & evidence

ORD record
ord-9f955af70a6c44499d8421b90d6fb4cf
Source dataset
uspto-grants-1996_11
Patent number
US05571810

Reaction notes

Loading…