反应详情

A mixture of 5-acetyl-2-(4-fluorophenyl)-3-[4-(methylsulfonyl)phenyl]thiophene (1 g), thallium(III) nitrate trihydrate (1.4 g) and perchloric acid (70%; 3 ml) in methanol (15 ml) and dioxane (7 ml) was stirred at ambient temperature for 7 hours. The insoluble material was filtered. The filtrate was diluted with water and extracted with chloroform. The extract was dried over magnesium sulfate and concentrated to give an oil of methyl 5-(4-fluorophenyl)-4-[4-(methylsulfonyl)phenyl]thiophene-2-acetate (1.2 g).

1. filtrationThe insoluble material was filtered
2. additionThe filtrate was diluted with water
3. extractionextracted with chloroform
4. dry with materialThe extract was dried over magnesium sulfate
5. concentrationconcentrated