反应详情

A mixture of 2-(4-fluorophenyl)-3-[4-(methylsulfonyl)phenyl]-5-nitrothiophene (3.6 g), iron powder (3.6 g) and ammonium chloride (0.36 g) in ethanol (58 ml) and water (22 ml) was stirred and refluxed for 1 hour. The insoluble was filtered and washed with N,N-dimethylformamide (40 ml). The filtrate was concentrated. The residue was triturated with water, filtered, and washed with water and ethanol to give a pale yellow powder of 5-(4-fluorophenyl)-4-[4-(methylsulfonyl)phenyl]-2-thiophenamine (2.7 g).

1. temperaturerefluxed for 1 hour
2. filtrationThe insoluble was filtered
3. washwashed with N,N-dimethylformamide (40 ml)
4. concentrationThe filtrate was concentrated
5. customThe residue was triturated with water
6. filtrationfiltered
7. washwashed with water and ethanol