反应详情

A mixture of 5-(4-fluorophenyl)-4-[4-(methylsulfonyl)phenyl]-2-thiophenamine (0.9 g) and methyl isocyanate (1.4 ml) in tetrahydrofuran (20 ml) was stirred and refluxed for 1 hour. The solvent was evaporated and the residue (1.5 g) was purified by column chromatography on silica gel eluting with a mixture of chloroform and methanol (10:1) to give a brown powder of N-{5-(4-fluorophenyl)-4-[4-(methylsulfonyl)phenyl]-2-thienyl}-N'-methylurea (0.77 g).

1. temperaturerefluxed for 1 hour
2. customThe solvent was evaporated
3. customthe residue (1.5 g) was purified by column chromatography on silica gel eluting with a mixture of chloroform and methanol (10:1)