Formamide → HCID 23372700, compound

HRID 1899100Notes

Reaction equation

HRID 1899100 reaction equation
[CH:1]([CH2:3][NH:4][C:5]1[CH:10]=[CH:9][C:8]([C:11]2[S:15][C:14](C(OCC)=O)=[CH:13][C:12]=2[C:21]2[CH:26]=[CH:25][C:24]([S:27]([CH3:30])(=[O:29])=[O:28])=[CH:23][CH:22]=2)=[CH:7][CH:6]=1)=[O:2].C[O-].[Na+].[CH:34]([NH2:36])=[O:35]>>[CH:1]([CH2:3][NH:4][C:5]1[CH:6]=[CH:7][C:8]([C:11]2[S:15][CH:14]=[C:13]([C:34]([NH2:36])=[O:35])[C:12]=2[C:21]2[CH:26]=[CH:25][C:24]([S:27]([CH3:30])(=[O:29])=[O:28])=[CH:23][CH:22]=2)=[CH:9][CH:10]=1)=[O:2]

Participants

4

Reactant 3

HCID 713FormamideHCID 10942334Sodium MethoxideHCID 23372733HCID 23372733, compound

Product 1

HCID 23372700HCID 23372700, compound

Conditions

Temperature
100 °C

Procedure

A mixture of ethyl 5-[4-(N-formylmethylamino)phenyl]-4-[4-(methylsulfonyl)phenyl]thiophene-2-carboxylate (0.34 g) and sodium methoxide (0.13 g) in formamide (2 ml) was stirred at 100° C. for 2.5 hours. The mixture was poured into ice-water and the precipitates were collected to give 5-[4-(N-formylmethylamino)phenyl]-4-[4-(methylsulfonyl)phenyl]thiophene-3-carboxamide (0.3 g).

Workup

  1. customthe precipitates were collected

Sources & evidence

ORD record
ord-2a20d1ac90f94f828498d9381d71879d
Source dataset
uspto-grants-1996_11
Patent number
US05571810

Reaction notes

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