Acetic Anhydride → HCID 23372713, compound

HRID 1899101Notes

Reaction equation

HRID 1899101 reaction equation
[C:1](OC(=O)C)(=[O:3])C.[NH2:8][C:9]1[CH:14]=[CH:13][C:12]([C:15]2[S:19][C:18]([C:20]([O:22][CH2:23][CH3:24])=[O:21])=[CH:17][C:16]=2[C:25]2[CH:30]=[CH:29][C:28]([S:31]([CH3:34])(=[O:33])=[O:32])=[CH:27][CH:26]=2)=[CH:11][CH:10]=1>C(O)=O>[CH:1]([NH:8][C:9]1[CH:10]=[CH:11][C:12]([C:15]2[S:19][C:18]([C:20]([O:22][CH2:23][CH3:24])=[O:21])=[CH:17][C:16]=2[C:25]2[CH:30]=[CH:29][C:28]([S:31]([CH3:34])(=[O:33])=[O:32])=[CH:27][CH:26]=2)=[CH:13][CH:14]=1)=[O:3]

Participants

4

Reactant 2

HCID 7918Acetic AnhydrideHCID 23372678HCID 23372678, compound

Product 1

HCID 23372713HCID 23372713, compoundYield 71%

Reagents, catalysts & solvents 1

HCID 284Formic AcidSolvent

Conditions

Temperature
50 °C

Procedure

A mixture of acetic anhydride (1.1 g) and formic acid (0.8 g) was heated at 50° C. for 30 minutes. To the mixture was added ethyl 5-(4-aminophenyl)-4-[4-(methylsulfonyl)phenyl]thiophene-2-carboxylate (0.5 g). The mixture was stirred at ambient temperature for 4 hours and poured into ice-water. The precipitates were collected, washed with water, and dried in vacuo to give ethyl 5-[4-(formylamino)phenyl]-4-[4-(methylsulfonyl)phenyl]thiophene-2-carboxylate (0.38 g).

Workup

  1. customThe precipitates were collected
  2. washwashed with water
  3. customdried in vacuo

Sources & evidence

ORD record
ord-0ec9bf9731a147ffb9ada66aedf3c67c
Source dataset
uspto-grants-1996_11
Patent number
US05571810

Reaction notes

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