Acetic Anhydride → HCID 23372713, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of acetic anhydride (1.1 g) and formic acid (0.8 g) was heated at 50° C. for 30 minutes. To the mixture was added ethyl 5-(4-aminophenyl)-4-[4-(methylsulfonyl)phenyl]thiophene-2-carboxylate (0.5 g). The mixture was stirred at ambient temperature for 4 hours and poured into ice-water. The precipitates were collected, washed with water, and dried in vacuo to give ethyl 5-[4-(formylamino)phenyl]-4-[4-(methylsulfonyl)phenyl]thiophene-2-carboxylate (0.38 g).

Provenance & Evidence