Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Methanesulfonyl chloride | HCID 31297 | — |
| Reactant | HCID 23372712 | HCID 23372712 | — |
| Solvent | Pyridine | HCID 1049 | — |
| Product | HCID 23372687 | HCID 23372687 | 87.1% |
Reaction Steps
A mixture of 5-[4-(N-formylmethylamino)phenyl]-4-[4-(methylsulfonyl)phenyl]thiophene-2-carboxamide (0.3 g) and methanesulfonyl chloride (0.5 g) in pyridine (1.5 ml) was stirred at 50° C. for 3 hours. The mixture was poured into dilute hydrochloric acid. The precipitates were collected and washed with water to give 5-[4-(N-formylmethylamino)phenyl]-4-[4-(methylsulfonyl)phenyl]thiophene-2-carbonitrile (0.25 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US05571810 |
|---|
| Source dataset | uspto-grants-1996_11 |
|---|
| ORD ID | ord-ce6981154c154bfcbd508937c556bf42 |
|---|
| Source note | uspto-grants-1996_11 |
|---|
