Hydrochloric Acid → HCID 23372687, compound

HRID 1899103Notes

Reaction equation

HRID 1899103 reaction equation
[CH:1]([CH2:3][NH:4][C:5]1[CH:10]=[CH:9][C:8]([C:11]2[S:15][C:14]([C:16]([NH2:18])=O)=[CH:13][C:12]=2[C:19]2[CH:24]=[CH:23][C:22]([S:25]([CH3:28])(=[O:27])=[O:26])=[CH:21][CH:20]=2)=[CH:7][CH:6]=1)=[O:2].CS(Cl)(=O)=O.Cl>N1C=CC=CC=1>[CH:1]([CH2:3][NH:4][C:5]1[CH:10]=[CH:9][C:8]([C:11]2[S:15][C:14]([C:16]#[N:18])=[CH:13][C:12]=2[C:19]2[CH:24]=[CH:23][C:22]([S:25]([CH3:28])(=[O:27])=[O:26])=[CH:21][CH:20]=2)=[CH:7][CH:6]=1)=[O:2]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 31297Methanesulfonyl chlorideHCID 23372712HCID 23372712, compound

Product 1

HCID 23372687HCID 23372687, compoundYield 87.1%

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Conditions

Temperature
50 °C

Procedure

A mixture of 5-[4-(N-formylmethylamino)phenyl]-4-[4-(methylsulfonyl)phenyl]thiophene-2-carboxamide (0.3 g) and methanesulfonyl chloride (0.5 g) in pyridine (1.5 ml) was stirred at 50° C. for 3 hours. The mixture was poured into dilute hydrochloric acid. The precipitates were collected and washed with water to give 5-[4-(N-formylmethylamino)phenyl]-4-[4-(methylsulfonyl)phenyl]thiophene-2-carbonitrile (0.25 g).

Workup

  1. customThe precipitates were collected
  2. washwashed with water

Sources & evidence

ORD record
ord-ce6981154c154bfcbd508937c556bf42
Source dataset
uspto-grants-1996_11
Patent number
US05571810

Reaction notes

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