Thionyl Chloride → 2-Chloronicotinoyl chloride

HRID 1899390Notes

Reaction equation

HRID 1899390 reaction equation
[Cl:1][C:2]1[N:10]=[CH:9][CH:8]=[CH:7][C:3]=1[C:4](O)=[O:5].S(Cl)([Cl:13])=O>>[Cl:1][C:2]1[N:10]=[CH:9][CH:8]=[CH:7][C:3]=1[C:4]([Cl:13])=[O:5]

Participants

3

Reactant 2

HCID 24386Thionyl ChlorideHCID 762582-Chloronicotinic acid

Product 1

HCID 27745412-Chloronicotinoyl chloride

Procedure

2-chloronicotinic acid chloride was prepared by refluxing 90g (0.571 mole) of 2-chloronicotinic acid in 315ml of thionylchloride for 2 hours. The excess thionylchloride was distilled off. The residue was diluted with 200ml of 1,4-dioxane and used as is.

Workup

  1. distillationThe excess thionylchloride was distilled off
  2. additionThe residue was diluted with 200ml of 1,4-dioxane

Sources & evidence

ORD record
ord-ca83247249cd4fd88a3a8bae7589e6f6
Source dataset
uspto-grants-1996_11
Patent number
US05571912

Reaction notes

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