Chloromethyl Methyl Ether → 1H-Pyrrole-3-carboxylic acid, 5-formyl-1-(methoxymethyl)-, methyl ester

HRID 1899399Notes

Reaction equation

HRID 1899399 reaction equation
[CH:1]([C:3]1[NH:4][CH:5]=[C:6]([C:8]([O:10][CH3:11])=[O:9])[CH:7]=1)=[O:2].Cl[CH2:13][O:14][CH3:15]>>[CH:1]([C:3]1[N:4]([CH2:13][O:14][CH3:15])[CH:5]=[C:6]([C:8]([O:10][CH3:11])=[O:9])[CH:7]=1)=[O:2]

Participants

3

Reactant 2

HCID 7864Chloromethyl Methyl EtherHCID 579027Methyl 5-formylpyrrole-3-carboxylate

Product 1

HCID 6028531H-Pyrrole-3-carboxylic acid, 5-formyl-1-(methoxymethyl)-, methyl ester

Procedure

reacting a methyl 2-formyl-4-pyrrolcarboxylate with chloromethyl-methyl-ether in the presence of a base and a suitable organic solvent, obtaining as a reaction product methyl 2-formyl-N-methoxymethyl-4-pyrrolcarboxylate;

Sources & evidence

ORD record
ord-8bb95edff52a4e959f8c81fdbc5575cb
Source dataset
uspto-grants-1996_11
Patent number
US05571927

Reaction notes

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