2-Thiophenesulfonyl chloride → HCID 15342056, compound

HRID 1899658Notes

Reaction equation

HRID 1899658 reaction equation
[NH2:1][C:2]1[O:6][N:5]=[C:4]([CH3:7])[C:3]=1[Br:8].[S:9]1[CH:13]=[CH:12][CH:11]=[C:10]1[S:14](Cl)(=[O:16])=[O:15]>>[Br:8][C:3]1[C:4]([CH3:7])=[N:5][O:6][C:2]=1[NH:1][S:14]([C:10]1[S:9][CH:13]=[CH:12][CH:11]=1)(=[O:16])=[O:15]

Participants

3

Reactant 2

HCID 855182-Thiophenesulfonyl chlorideHCID 104875194-Bromo-3-methylisoxazol-5-amine

Product 1

HCID 15342056HCID 15342056, compoundYield 34%

Procedure

N-(4-Bromo-3-methyl-5-isoxazolyl)-2-thiophenesulfonamide was prepared from 5-amino-4-bromo-3-methylisoxazole and 2-thiophenesulfonyl chloride according to the procedures described in Example 45. The crude product was purified by recrystallization from ethyl acetate/hexanes to give a crystalline solid, m.p. 125°-127° C., yield 34%.

Workup

  1. customThe crude product was purified by recrystallization from ethyl acetate/hexanes
  2. customto give a crystalline solid, m.p. 125°-127° C., yield 34%

Sources & evidence

ORD record
ord-955d7f0bb3c44dc59e9cec5518112157
Source dataset
uspto-grants-1996_11
Patent number
US05571821

Reaction notes

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